The Amyloid Precursor Protein (APP) processing as a biological link between Alzheimer's Disease and Cancer.

The Amyloid Precursor Protein (APP) processing as a biological link between Alzheimer's Disease and Cancer. Ageing Res Rev. 2018 Nov 27;: Authors: Galvão F, Grokoski KC, da Silva BB, Lamers ML, Siqueira IR Abstract Aging is a risk factor for several illnesses, such as Alzheimer's Disease and various cancers. However, an inverse correlation between malignancies and Alzheimer's Disease has been suggested. This review addressed the potential role of non-amyloidogenic and amyloidogenic pathways of amyloid precursor protein processing as a relevant biochemical mechanism to clarify this association. Amyloidogenic and non-amyloidogenic pathways have been related to Alzheimer's Disease and certain malignancies, respectively. Several known molecules involved in APP processing, including its regulation and final products, were summarized. Among them some candidate mechanisms emerged, such as extracellular-regulated kinase (Erk) and protein kinase C (PKC). Therefore, the imbalance of APP processing may be involved with the negative correlation between cancer and Alzheimer Disease. PMID: 30500566 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research