Interaction between stress and the Val66Met polymorphism in depression: A systematic review and meta-analysis

Background: Major depression is a disabling psychiatric illness with complex origins. Life stress (childhood adversity and recent stressful events) is a robust risk factor for depression. The relationship between life stress and Val66Met polymorphism in the Brain-derived neurotrophic factor [BDNF] gene has received much attention. The aim of the present study is to review and meta-analyze the results from published studies examining this interaction.
Source: Comprehensive Psychiatry - Category: Psychiatry Authors: Source Type: research