Impact of NPM1 mutation subtypes on treatment outcome: the Lyon-University Hospital experience

The nucleophosmin member 1 (NPM1) is an abundant multifunctional nucleolar protein involved in the maintenance of genome stability and ribosome biogenesis [1]. Mutations in the NPM1gene are detected in approximately one-third of all patients with acute myeloid leukemia (AML) and up to 60% of those with normal cytogenetics [2]. The gene encoding NPM1 is located on 5q35.1 and contains 12 exons. NPM1 is involved in epigenetic control, ribosomal protein assembly, and regulation of p53 tumor suppressor pathway [3].
Source: Leukemia Research - Category: Hematology Authors: Tags: LETTER TO THE EDITOR Source Type: research