Insulin Reduces Reaction of Follicular Granulosa Cell to FSH Stimulation in Obesity-Related Infertility Women during IVF.

Conclusions: Obesity was associated with reduced FSHR expression and E2 production in IVF women, caused by dysfunctional insulin pathway. Decreased FSHR expression in hGCs from obese women and insulin-treated KGN could be rescued by inhibition of GSK3β, which might be a potential target for improving the impaired FSH response in obese women.
PMID: 30476103 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - November 21, 2018 Category: Endocrinology Authors: Xu P, Huang BY, Zhan JH, Liu MT, Fu Y, Su YQ, Sun QY, Wang WH, Chen DJ, Liu JQ Tags: J Clin Endocrinol Metab Source Type: research