Association between tissue inhibitor of metalloproteinase (TIMP) genetic polymorphisms and primary ovarian insufficiency (POI)

Primary ovarian insufficiency (POI), also known as premature ovarian insufficiency, premature menopause, and hypergonadotropic hypogonadism, is the loss of ovary function before the age of 40 [1]. POI occurs in 1% of the general population, affects 10% of non-ovulating women, and causes infertility and a deficiency in sex steroid production [2]. POI is diagnosed by elevated gonadotropin levels, including levels of serum follicle stimulating hormone (FSH)>40 IU/L after puberty. Recently proposed guidelines for POI diagnosis include a serum FSH  > 30 IU/L after puberty [3].

Source: Maturitas - November 27, 2018 Category: Primary Care Authors: Hui Jeong An, Eun Hee Ahn, Jung Oh Kim, Han Sung Park, Chang Soo Ryu, Sung Hwan Cho, Ji Hyang Kim, Woo Sik Lee, Nam Keun Kim Source Type: research