Reduced pain thresholds and signs of sensitization in women with persistent pelvic pain and suspected endometriosis

ConclusionOur results showed widespread alterations in pain thresholds in women with persistent pelvic pain that are indicative of central sensitization and a time ‐dependent correlation. Women with pelvic pain and suspicion of endometriosis should probably be treated more thoroughly in order to prevent or at least minimize the concomitant development of central sensitization.This article is protected by copyright. All rights reserved.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: Original Research Article Source Type: research

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ConclusionsImprovement of general QoL and most of gastrointestinal symptoms was documented after SR.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
ConclusionMinimal preoperative factors are associated with nonresponse for women having surgery for endometriosis. The severity of pain experienced by women with endometriosis may be used to predict their response to surgery.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionThere are minimal pre-operative factors that are associated with non-response for women having surgery for endometriosis. The severity of pain experienced by women with endometriosis may be used to predict their response to surgery.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Conclusion: The findings of this study will provide convincing evidence to determine whether PC therapy is an effective and safe intervention for patients with endometriosis. PROSPERO registration number: PROSPERO CRD42019123292.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
AbstractEndometriosis is a gynecological condition affecting 10% of women in reproductive age. High rates of depression and anxiety are observed in these patients. The mechanisms underlying endometriosis-induced behavioral alterations are still elusive. Animal models provide a useful tool to study the temporal sequence and biological pathways involved in this disease and comorbid states. Here, we sought to characterize time-related behavioral alterations in rats submitted to endometriosis model (EM) induced by peritoneal auto-transplantation of uterine tissues weekly for three weeks. Corticosterone stress reactivity, oxida...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
Semin Reprod Med 2018; 36: 116-122 DOI: 10.1055/s-0038-1676088Dysmenorrhea and noncyclic pelvic pain (chronic pelvic pain) are common in adolescents. The evaluation of teens with dysmenorrhea or chronic pelvic pain is aimed to diagnose possible gynecologic conditions (endometriosis, pelvic inflammatory disease, ovarian cysts, and obstruction of the reproductive tract) and nongynecologic conditions (irritable bowel syndrome, interstitial cystitis, and myofascial pain). The management of chronic pelvic pain in adolescents is often more complex than in adult women because both the adolescent and her parents are counseled and ...
Source: Seminars in Reproductive Medicine - Category: Reproduction Medicine Authors: Tags: Review Article Source Type: research
Abstract Endometriosis is an estrogen-dependent inflammatory disorder among reproductive-aged women associated with pelvic pain, anxiety, and depression. Pain is characterized by central sensitization, however it is not clear if endometriosis leads to increased pain perception or if women with the disease are more sensitive to pain, increasing the detection of endometriosis. Endometriosis was induced in mice and changes in behavior including pain perception, brain electrophysiology, and gene expression were characterized. Behavioral tests revealed that mice with endometriosis were more depressed, anxious and sensi...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
This study was financed by Italian fiscal contribution ‘5 × 1000’—Ministero dell’Istruzione, dell’Università e della Ricerca—devolved to Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy. P.V., M.P.F., R.R., D.D., A.R., P.M., O.D.G. and M.C. declare that they have no co nflicts of interest. E.S. received grants from Ferring and Serono.
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
In August, The New York Times published a guest op-ed by a man named David Roberts who suffered from severe chronic pain for many years before finally finding relief. The piece immediately went viral, with distinguished news journalist and personality Dan Rather posting it to his Facebook page with the addendum that it could “offer hope” to some pain patients. However, for many of us in the chronic pain community, particularly women, the piece was regarded with weariness and frustration. The first and most prominent source of annoyance for me regarding this piece was the part when the author finally discloses h...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Behavioral Health Pain Management Women's Health Source Type: blogs
This study aim to determine if endometriosis could cause central pain sensitization, anxiety and depression in a mouse model and the molecular changes in the brain that are mechanistically responsible.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Oral session Source Type: research
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