Small molecule nAS ‐E targeting cAMP response element binding protein (CREB) and CREB‐binding protein interaction inhibits breast cancer bone metastasis
In this study, we tested the effect of nAS‐E on breast cancer cell proliferation, survival, migration as well as osteoclast formation and bone resorption in vitro for the first time. Our results demonstrated that nAS‐E inh ibited breast cancer cell proliferation, migration, survival and suppressed osteoclast differentiation as well as bone resorption through inhibiting CREB‐CBP interaction. In addition, the in vivo effect of nAS‐E in protecting against breast cancer‐induced osteolysis was evaluated. Our results indicated that nAS‐E could reverse bone loss induced by MDA‐MB‐231 tumour. These results suggest that small molecules targeting CREB‐CBP interaction to inhibit CREB‐mediated gene transcription might be a potential approach for the treatment of breast cancer bone metastasis.
Source: Journal of Cellular and Molecular Medicine - Category: Molecular Biology Authors: Min Jiang,
Yufei Yan,
Kai Yang,
Zhuochao Liu,
Jin Qi,
Hanbing Zhou,
Niandong Qian,
Qi Zhou,
Tianqi Wang,
Xing Xu,
Xiangshu Xiao,
Lianfu Deng Tags: ORIGINAL ARTICLE Source Type: research
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