Quantitative parameters correlated well with differentiation of squamous cell carcinoma at head and neck: a study of dynamic contrast-enhanced MRI.
Quantitative parameters correlated well with differentiation of squamous cell carcinoma at head and neck: a study of dynamic contrast-enhanced MRI. Acta Radiol. 2018 Nov 20;:284185118809543 Authors: Dong Ji X, Yan S, Xia S, Guo Y, Shen W Abstract BACKGROUND: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is widely used for the diagnosis and prognostic assessment of head and neck squamous cell carcinoma (HNSCC). However, no research on grading HNSCC using DCE-MRI has been found. We hypothesize that DCE-MRI can grade the HNSCC non-invasively. PURPOSE: To verify the hypothesis that DCE-MRI can grade the HNSCC non-invasively. MATERIAL AND METHODS: Forty-two patients with histopathologically proved HNSCC from September 2013 to February 2016 were retrospectively analyzed. Chi-square test was used to compare patterns of time intensity curves (TICs) between well and poorly differentiated HNSCC. Two-sample t-test was performed to calculate the difference of volume transfer constant (Ktrans), extravascular extracellular volume fraction (Ve), and initial area under the curve (iAUC) between groups. The diagnostic ability and cut-off value were assessed by receiver operator characteristic analysis. RESULTS: Most TICs of HNSCC are type III; no difference between well and poorly differentiated HNSCC has been found ( P > 0.05). The value of Ktrans, Ve, and iAUC for well and poorly differentiated HNSCC are (0.218 &pl...
Authors: Feng X, Zhang M, Meng J, Wang Y, Liu Y, Liang C, Fan S Abstract We aimed to investigate the potential mechanisms of progression and identify novelprognosis-related biomarkers for papillary renal cell carcinoma (PRCC) patients. The relateddata were derived from The Cancer Genome Atlas (TCGA), and then, analyzed by Weightedgene co-expression network analysis (WGCNA). The correlation between each module andthe clinical traits were analyzed by Pearson's correlation analysis. Pathway analysis wasconducted to reveal potential mechanisms. Hub genes within each module were screenedby intra-module analysis, and vis...
CONCLUSION: The results of this this study indicate that the LBM combination can be used as a therapeutic for ameliorating NAFLD via modulating the gut microbiota and improving insulin resistance. PMID: 31950772 [PubMed - as supplied by publisher]
Conclusions: Active surveillance is possible in developing western countries with similar results to those provided by Asian and American authors. PMID: 31950887 [PubMed - as supplied by publisher]
ConclusionHaptoglobin bifucosylated tetra-antennary glycan is associated with the presence of HCC in patients with chronic liver disease including those without cirrhosis. Its combination with existing HCC biomarkers could improve the performance of standard AFP for HCC detection.
ConclusionIn summary, our data reveal a novel molecular mechanism by which wogonin induces HCC cells cycle arrest and suppresses tumor proliferation.Graphical abstract
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...
ConclusionsActivation of Wnt/β-catenin signaling pathway is an early event in HNSCC carcinogenesis. Lineage tracing using the Axin2-CreER reporter may link TICs properties with a fundamental signaling pathway in normal development. Further research is required to clarify the role of Wnt-responsive TICs in recurrence and therapy resistance of HNSCC.