Association of VDR ‐FokI and VDBP‐Thr420Lys polymorphisms with cervical spondylotic myelopathy: A case‐control study in the population of China

ConclusionBinary logistic regression analysis confirmed thatVDR‐FokI polymorphism and the time to bend over desk working were risk factors of CSM. Our results indicate thatVDR‐FokI polymorphism may be closely associated with the risk of CSM.
Source: Journal of Clinical Laboratory Analysis - Category: Laboratory Medicine Authors: Tags: RESEARCH ARTICLE Source Type: research

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The eGaIn coil on neoprene demonstrated in this paper presents a stretchable radio frequency receive coil for magnetic resonance imaging (MRI). The coil with dimensions $text{86 mm}times text{70 mm}$ is tuned to resonate at 128 MHz for 3 T MRI. We investigate the effect of stretching (up to 40% strain) and bending (50 mm radius of curvature) of the coil on the coil's resistance and resonance frequency. Measurements and simulations show a decrease in resonance frequency of 2.5 MHz per 10% strain. The higher resistivity of liquid metal compared to copper reduces the SNR of MRI scans by 34%; therefore, a...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
In this paper, a set of novel whole-body gradient coils is designed for cylindrical magnetic resonance imaging (MRI) systems. For the sake of high coil efficiency, the design scheme focuses on the imaging volume occupied by the patient, discounting the large space under the patient bed that is unused during imaging. To further improve the coil performance, the coils are designed on an unconventional, hybrid cylindrical-planar structure, where the primary coils are arranged on a chord-truncated cylindrical former while the shielding coils remain on the cylindrical assemblies. In this new coil configuration, the primary laye...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Strong electromagnetic fields that occur during functional magnetic resonance imaging (fMRI) presents a challenging environment for concurrent electrophysiological recordings. Here, we present a miniaturized, wireless platform—“MR-Link” (Multimodal Recording Link) that provides a hardware solution for simultaneous electrophysiological and fMRI signal acquisition. The device detects the changes in the electromagnetic field during fMRI to synchronize amplification and sampling of electrophysiological signals with minimal artifacts. It wirelessly transmits the recorded data at a frequency detectable by the M...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
AbstractWhite matter alterations related to hypocretin pathway have been less evaluated in patients who have narcolepsy with cataplexy (NC), as compared to the identified exploration of gray matter and have varied among structural brain magnetic resonance imaging studies. The aim of this study was to investigate the disruption of specific white matter tracts in drug-na ïve patients with NC, by using a tract-specific statistical analysis (TSSA). Forty drug-naïve NC patients with cataplexy and 42 heathy controls were enrolled in the study. All participants completed diffusion weighted imaging, polysomnography, and ...
Source: Brain Imaging and Behavior - Category: Neurology Source Type: research
Researchers have used functional magnetic resonance imaging  to show how cannabidiol counteracts some of the harmful effects of cannabis on the brain.
Source: Clinical Pharmacist - Category: Drugs & Pharmacology Source Type: research
Nanotechnology in medicine has greatly expanded the therapeutic strategy that may be explored for cancer treatment by exploiting the specific tumor microenvironment such as mild acidity, high glutathione (GSH)...
Source: Journal of Nanobiotechnology - Category: Nanotechnology Authors: Tags: Research Source Type: research
This cross-sectional study of a cohort of the Age, Gene/Environment Susceptibility –Reykjavik Study determines whether unrecognized myocardial infarction detected by cardiac magnetic resonance imaging is associated with cerebral infarction.
Source: JAMA Neurology - Category: Neurology Source Type: research
Publication date: Available online 18 May 2019Source: NeuroImageAuthor(s): Bernadet L. Klaassens, Joop M.A. van Gerven, Erica S. Klaassen, Jeroen van der Grond, Serge A.R.B. RomboutsAbstractDisruption of cholinergic and serotonergic neurotransmitter systems is associated with cognitive, emotional and behavioural symptoms of Alzheimer's disease (AD). To investigate the responsiveness of these systems in AD we measured the effects of a single-dose of the selective serotonin reuptake inhibitor citalopram and acetylcholinesterase inhibitor galantamine in 12 patients with AD and 12 age-matched controls on functional brain conne...
Source: NeuroImage - Category: Neuroscience Source Type: research
by Casey Paquola, Reinder Vos De Wael, Konrad Wagstyl, Richard A. I. Bethlehem, Seok-Jun Hong, Jakob Seidlitz, Edward T. Bullmore, Alan C. Evans, Bratislav Misic, Daniel S. Margulies, Jonathan Smallwood, Boris C. Bernhardt While the role of cortical microstructure in organising neural function is well established, it remains unclear how structural constraints can give rise to more flexible elements of cognition. While nonhuman primate research has demonstrated a close structure–function correspondence, the relatio nship between microstructure and function remains poorly understood in humans, in part because of the r...
Source: PLoS Biology: Archived Table of Contents - Category: Biology Authors: Source Type: research
AbstractPurpose of ReviewThe purpose of this review is to answer the question whether left ventricular hypertrophy (LVH) could be considered a therapeutic target in patients with hypertension. To fulfill this purpose, we briefly outline different methods of measuring LVH, then discuss the current evidence and unresolved controversies regarding the relationships among LVH, blood pressure (BP), and cardiovascular disease (CVD) outcomes.Recent FindingsThe methods and criteria used for defining LVH in clinical studies lack consistency and are inherently different. Electrocardiogram (ECG) has been the most common method, but so...
Source: Current Hypertension Reports - Category: Primary Care Source Type: research
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