Bronchoalveolar lavage transcriptome and eicosanoid profiles reveal heterogeneity of lower airway inflammation in aspirin-exacerbated respiratory disease (AERD)

Conclusions: We revealed endotypic heterogeneity of AERD asthma. Lipidomic signature of AERD (i.e. higher production of LTE4) is strongly linked with lower airway eosinophilia and can be observed only in a subset of patients with eosinophilic AERD phenotype.

http://erj.ersjournals.com/cgi/content/short/52/suppl_62/PA5010?rss=1

Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Jakieła, B., Gielicz, A., Plutecka, H., Przybyszowski, M., Soja, J., Sładek, K., Bochenek, G. Tags: Allergy and immunology Source Type: research