Safety and efficacy of reduced dose intrapleural alteplase and DNAase for pleural infection

Conclusions: Our data suggest that 2.5mg alteplase and 5mg DNase is safe and effective even in high risk patients. A larger prospective study will be needed to confirm this. 90% of patients received 3 doses or less.References:1) Popowicz N et al. Dose De-escalation of Intrapleural Tissue Plasminogen Activator Therapy for Pleural Infection. Ann Am Thorac Soc. 2017 Jun;14(6):929-936.

Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Ip, H., West, A., Wallace, D., Noorzad, F., Ahmed, L. Tags: Respiratory infections Source Type: research