Prevalence of co-morbidities and clinical features in patients with obstructive sleep apnea and chronic obstructive pulmonary disease.

This study aimed to compare the prevalence of co-morbidities and the clinical features in patients with OSA and OS. We analyzed demographic, polygraphic data and co-morbidities from two cohorts of patients, 69 (45 males) with OSA (FVC 94% FEV1 93%) and 79 (65 males) with OS (FVC 82% FEV1 65 %). There were no significant differences between the two groups in demographics (age 67±12 vs 69 ±8, BMI 33.6±6 vs 32±6, OSA vs OS), epworth sleepiness scale (7.7±6 vs 9±4, OSA vs OS) and Mallampati score (3.2±0.1 vs 3.0±01, OSA vs OS.) The two groups had comparable apnea/hypopnea index (AHI) (43.2±21 vs 42.2±21) but different diurnal SaO2 % (94.6 ±1 OSA vs 93.6±2 OS, P<0.05), mean nocturnal SaO2 %(90.3 ±1 OSA vs 89.0±5 OS, P<0.05) and SaO2 T90 (29.5±24 OSA vs 46.9±30 OS, P<0.0001). Hypertension, diabetes, gastroesophageal reflux (GR) and dyslipidemia were the most frequent disorders in the whole cohort. A difference was found in the prevalence of dyslipidemia (13% OSA vs 22% OS, P<0.05), but not in the prevalence of hypertension(70% OSA vs 67% OS, NS), diabetes(24% OSA vs 26% OS, NS), GR (7% OSA vs 7% OS, NS) or previous cerebrovascular accidents (4% OSA vs 7% OS, NS). We conclude that patients with OS, as compared to patients with OSA, with equal AHI, exibit a worse oxygenation but a similar prevalence of important co-morbidities.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research