The required coefficient of friction in Parkinson's disease: people with freezing of gait.

The required coefficient of friction in Parkinson's disease: people with freezing of gait. Funct Neurol. 2018 Jul/Sept;33(3):137-142 Authors: Rozin Kleiner AF, Cubillos DM, Pinto C, Salazar AP, Marchese RR, Barros RML, Galli M, Pagnussat AS Abstract The required coefficient of friction (RCOF) is frequently reported in the literature as an indicator of slip propensity, a consequence of the collisional aspect of legged locomotion. Little is known about the RCOF in pathological gait. Therefore, this study aimed to quantify the RCOF in subjects with Parkinson's disease (PD) and freezing of gait (FOG) during the OFF-pharma phase, and to investigate the interplay between RCOF parameters and ankle kinematic and kinetic gait variables. Fourteen subjects with PD and 14 healthy age-matched subjects were instructed to walk barefoot at self-selected speed over a force platform. The RCOF curve was obtained as the ratio between the tangential and vertical ground reaction forces. Then, the following discrete variables were identified: P1COF (the peak at the loading response phase), V1COF (the valley at midstance phase) and P2COF (the peak at push-off phase). Stepwise multiple regressions were applied to observe the influence of the gait speed and ankle kinematic and kinetic gait variables on RCOF variables. In subjects with PD and FOG the gait speed is a predictor of the RCOF in the loading response phase; plantarflexion and the plantarflexion moment are strong predicto...
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research

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Publication date: Available online 7 December 2019Source: Progress in NeurobiologyAuthor(s): M.M.J. van den Berg, J. Krauskopf, J.G. Ramaekers, J.C.S. Kleinjans, J. Prickaerts, J.J. BriedéAbstractCirculating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as promising biomarkers for central nervous system (CNS) disorders because they are actively secreted as messengers and are profoundly involved in fine-tuning of developmental and differentiation processes. Furthermore, they are attractive biomarkers becau...
Source: Progress in Neurobiology - Category: Neuroscience Source Type: research
Authors: Fernandes B, Barbieri FA, Arthuso FZ, Silva FA, Moretto GF, Imaizumi LFI, Ngomane AY, Guimarães GV, Ciolac EG Abstract PURPOSE: To investigate the effect of high-intensity interval training (HIIT) versus moderate-intensity continuous exercise training (MICE) on hemodynamic and functional variables in individuals with Parkinson's disease. METHODS: Twenty participants (13 men) were randomly assigned to a thrice-weekly HIIT (n = 12) or MICE (n = 8) for 12 weeks. Hemodynamic (resting heart rate and blood pressure, carotid femoral pulse wave velocity, endothelial reactivity, and heart rate variabilit...
Source: Journal of Physical Activity and Health - Category: Sports Medicine Tags: J Phys Act Health Source Type: research
OBJECTIVE: We aimed to determine suicide risk and lifetime suicidal ideation in Parkinson disease (PD) patients versus controls and how depression, demoralization, and insomnia are associated with suicidality. METHODS: In this case-control study, P...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Conclusion: The BI and mRS showed acceptable validity and reliability to measure the degree of disability in patients with PD in daily activities in both ON and OFF medication phases.
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
DiscussionThese findings provide evidence supporting the use of technology-driven interventions aiming at alleviating rhythm-related motor deficits in PD such as hypokinetic dysarthria or gait impairment in complement to more traditional therapeutic approaches.
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
ConclusionsOur results showed that VADL and ABC questionnaires, applied before and after rehabilitation, were important tools to measure the independence, confidence and balance while developing daily activities. VADL and ABC questionnaires may effectively contribute to quantify the effect of the applied therapeutics and, consequently, its impact on the quality of life of patients with PD.
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
ConclusionsStimulation of STN at 80 Hz and 130 Hz may have different effects on proximal and distal muscle control. One hundred and thirty Hertz may have a small advantage for distal hand muscles, whereas 80 Hz is more effective in improving proximal muscle function.
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
Discussion/conclusionCette étude suggère que la SCP de la RLM ne permet pas d’améliorer significativement les capacités locomotrices et le contrôle postural des patients avec maladie de Parkinson évoluée. Une meilleure compréhension des mécanismes neuronaux impliquant cette région cérébrale dans la survenue de ces troubles reste nécessaire à l’élaboration de nouvelles stratégies thérapeutiques.
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
ConclusionLes tâches de résolution de conflit entraînent une altération de l’initiation du pas similaire chez les freezers, non-freezers et témoins. L’électroencéphalographie durant l’ANT combiné à l’initiation du pas semble être pertinente pour une meilleure compréhension de l’influence de l’attention sur l’initiation du pas dans la maladie de Parkinson.
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
Discussion/conclusionFallers distinguished from non-fallers by disease duration and motor impairment but adding gait measurement improves the accuracy of the clinical data. Further research should concentrate to validate these models in prospective cohorts.
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
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