GSE111474 Distinct constitutive and pathogen-induced transcriptional programs in dendritic cells derived from CD16- versus CD16+ monocytes

Contributors : Vanessa S Wacleche ; Jean-Philippe Goulet ; Am élie Cattin ; Dominique Gauchat ; Annie Gosselin ; Aurélie Cleret-Buhot ; Yuwei Zhang ; Cécile Tremblay ; Jean-Pierre Routy ; Petronela AncutaSeries Type : Expression profiling by arrayOrganism : Homo sapiensClassical CD16- versus intermediate/non-classical CD16+ monocytes differ in their homing potential and immunological functions; but whether they differentiate into dendritic cells (DC) with distinct contributions to immunity against bacterial/viral pathogens remains poorly investigated. Here, we employed a systems biology approach to identify differences between CD16+ and CD16- monocyte-derived DC (MDDC) with potential clinical relevanceAlthough both CD16+ and CD16- MDDC acquire classical DC markers in vitro, genome-wide transcriptional profiling revealed unique molecular signatures for CD16+ MDDC, including adhesion molecules (CD103), transcription factors (TCF4), enzymes (ALDH1L2), and chemokines (CCL22).
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research