Investigation of the mechanisms mediating MDMA “Ecstasy”-induced increases in cerebro-cortical perfusion determined by btASL MRI

Conclusions Cortical 5-HT depletion is associated with increases in perfusion although this mechanism alone does not account for MDMA-related changes. A role for NO, a key regulator of cerebrovascular perfusion, is implicated in MDMA-induced increases in cortical perfusion.

http://link.springer.com/10.1007/s00213-014-3790-0

Source: Psychopharmacology - November 1, 2014 Category: Psychiatry Source Type: research