MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease

Sickle cell disease (SCD) is a genetic disorder caused by the βS-globin mutation leading to production of hemoglobin S, polymer formation under low oxygen conditions, and red blood cell sickling. The net outcome of this process is chronic hemolysis, oxidative stress, anemia, and vaso-occlusive episodes of pain and organ damage. The most effective treatment fo r SCD is fetal hemoglobin (HbF; α2γ2) induction, which inhibits sickle hemoglobin polymerization through the formation of hybrid molecules [1].

Source: Experimental Hematology - November 6, 2018 Category: Hematology Authors: Biaoru Li, Xingguo Zhu, Christina M. Ward, Athena Starlard-Davenport, Mayuko Takezaki, Amber Berry, Alexander Ward, Caroline Wilder, Cindy Neunert, Abdullah Kutlar, Betty S. Pace Source Type: research