Genomic updates in understanding PTSD

Publication date: Available online 16 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Sumeet Sharma, Kerry J. ResslerAbstractTwin studies as well as more recent genetics-based heritability analyses demonstrate that up to 40 to 50% of the variance in predicting PTSD following trauma is heritable. However, most of the specific gene pathways and mechanism that mediate risk vs. resilience for PTSD following trauma exposure have yet to be elucidated. This review will examine the latest results from large scale Genome-wide association studies as well as other approaches aimed at understanding mechanisms of development of and recovery from PTSD.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research