Abnormal Immunolabeling of SMAD4 in Cell Block Specimens Distinguish Malignant and Benign Pancreatic Cells

ConclusionsDecreased SMAD4 immunolabeling provided improved sensitivity as compared to negative SMAD4 immunolabeling; therefore, it is important to compare SMAD4 expression in a sample to its expression in normal cells. Abnormal SMAD4 labeling showed low sensitivity and high specificity; therefore, SMAD4 staining using EUS ‐FNA samples might be helpful to detect malignancies that possessSMAD4 gene abnormalities.This article is protected by copyright. All rights reserved.

Source: Cytopathology - November 12, 2018 Category: Pathology Authors: Yoko Matsuda, Shikine Esaka, Akemi Suzuki, Yuri Hamashima, Masayuki Imaizumi, Miho Matsukawa, Yuko Fujii, Junko Aida, Kaiyo Takubo, Toshiyuki Ishiwata, Makoto Nishimura, Tomio Arai Tags: Original Article Source Type: research