Estimating the elimination feasibility in the 'end game' of control efforts for parasites subjected to regular mass drug administration: Methods and their application to schistosomiasis

by Arathi Arakala, Christopher M. Hoover, John M. Marshall, Susanne H. Sokolow, Giulio A. De Leo, Jason R. Rohr, Justin V. Remais, Manoj Gambhir Progress towards controlling and eliminating parasitic worms, including schistosomiasis, onchocerciasis, and lymphatic filariasis, is advancing rapidly as national governments, multinational NGOs, and pharmaceutical companies launch collaborative chemotherapeutic control campaigns. Critical questi ons remain regarding the potential for achieving elimination of these infections, and analytical methods can help to quickly estimate progress towards—and the probability of achieving—elimination over specific timeframes. Here, we propose theeffective reproduction number,Reff, as a proxy of elimination potential for sexually reproducing worms that are subject to poor mating success at very low abundance (positive density dependence, or Allee effects).Reff is the number of parasites produced by a single reproductive parasite at a given stage in the transmission cycle, over the parasite ’s lifetime—it is the generalized form of the more familiar basic reproduction number,R0, which only applies at the beginning of an epidemic —and it can be estimated in a ‘model-free’ manner by an estimator (‘ε’). We introduce ε, demonstrate its estimation using simulated data, and discuss how it may be used in planning and evaluation of ongoing elimination efforts for a range of parasitic ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research

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Source: NYT - Category: American Health Authors: Tags: Ebola Virus World Health Organization United Nations Congo, Democratic Republic of (Congo-Kinshasa) Tedros Adhanom Ghebreyesus Medicine and Health Epidemics your-feed-healthcare Source Type: news
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Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
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Source: The Journal of Parasitology - Category: Parasitology Authors: Tags: J Parasitol Source Type: research
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Source: The Journal of Parasitology - Category: Parasitology Authors: Tags: J Parasitol Source Type: research
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Source: Turkish Society for Parasitology - Category: Parasitology Authors: Tags: Turkiye Parazitol Derg Source Type: research
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