Glucose metabolism in the brain in LMNB1 ‐related autosomal dominant leukodystrophy

ConclusionsGlobal reduction of grey matter glucose metabolism in this white matter disease most likely depends on a combination of cortical afferent dysfunction and, in later stages, neuronal loss. The lowest metabolism in the cerebellum is consistent with histopathological findings and prominent cerebellar symptoms.

Source: Acta Neurologica Scandinavica - September 25, 2018 Category: Neurology Authors: Johannes Finnsson, Mark Lubberink, Irina Savitcheva, David F ällmar, Atle Melberg, Eva Kumlien, Raili Raininko Tags: ORIGINAL ARTICLE Source Type: research