Coagulation Failure in Patients With Acute ‐on‐Chronic Liver Failure and Decompensated Cirrhosis: Beyond the International Normalized Ratio

Conclusion: Patients with ACLF frequently show hypocoagulable features with prolonged time to initial fibrin formation and clot formation time and reduced clot firmness; these alterations worsen after admission, correlate with systemic inflammation, and translate into higher short ‐term mortality; hypofibrinolysis could contribute to organ failure in ACLF.

https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.30103?af=R

Source: Hepatology - November 9, 2018 Category: Internal Medicine Authors: Annabel Blasi, Andrea Calvo, Ver ónica Prado, Enric Reverter, Juan Carlos Reverter, María Hernández‐Tejero, Fátima Aziz, Alex Amoros, Andres Cardenas, Javier Fernández Tags: Original Article Source Type: research