Microvessels may Confound the “Swallow Tail Sign” in Normal Aged Midbrains: A Postmortem 7 T SW‐MRI Study

CONCLUSIONBoth iron deposits and microvessels contribute to the hyposignal surrounding nigrosome 1 in susceptibility weighted imaging of normal aged midbrains at ultrahigh ‐field strength. When assessing the substantia nigra for the presence or absence of the “swallow tail sign,” intrinsic vessels may be a sporadic confounder.
Source: Journal of Neuroimaging - Category: Radiology Authors: Tags: Short Communication Source Type: research

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CONCLUSIONS: The Korean MDS-UPDRS has the same overall structure as the English MDS-UPDRS. Our translated scale can be designated as the official Korean MDS-UPDRS. PMID: 33029970 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
CONCLUSIONS The expression of lncRNAs in peripheral blood differed significantly in PD patients and controls. These differentially expressed lncRNAs may play a role in the development of PD. PMID: 33031356 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Parkinson's disease (PD) patients with freezing of gait (FOG) can suddenly lose their forward moving ability leading to unexpected falls. To overcome FOG and avoid the falls, a real-time accurate FOG detection or prediction system is desirable to trigger o...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Freezing of gait (FOG) is a sudden cessation of locomotion in advanced Parkinson's disease (PD). A FOG episode can lead to falls, decreased mobility, and decreased overall quality of life. Prediction of FOG episodes provides an opportunity for intervention...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Abstract As the global population ages, the incidence of neurodegenerative diseases has risen. Furthermore, it has been suggested that depression, especially in elderly people, may also be an indication of latent neurodegeneration. Stroke, Alzheimer's disease (AD), and Parkinson's disease (PD) are usually accompanied by depression. The urgent challenge is further enforced by psychiatric comorbid conditions, particularly the feeling of despair in these patients. Fortunately, as our understanding of the neurobiological substrates of maladies affecting the central nervous system (CNS) has increased, more therapeutic ...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
Parkinson ’s disease (PD) is a common neurodegenerative condition associated with a wide range of motor and non-motor symptoms. There has been increasing interest in the potential benefit of performing arts as ...
Source: BMC Neurology - Category: Neurology Authors: Tags: Research article Source Type: research
Freezing of gait (FOG) in Parkinson's disease (PD) is the main cause of falling and greatly decreases the quality of life. The causes of FOG include not only motor symptoms such as rigidity and bradykinesia, but also non-motor symptoms such as cognitive decline and anxiety.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Correspondence Source Type: research
Authors: Lu R, Xu Y, Li X, Fan Y, Zeng W, Tan Y, Ren K, Chen W, Cao X Abstract Parkinson's disease (PD) decreases the quality of life of the affected individuals. The incidence of PD is expected to increase given the growing aging population. Motor symptoms associated with PD render the patients unable to self-care and function properly. Given that several drugs have been developed to control motor symptoms, highly sensitive scales for clinical evaluation of drug efficacy are needed. Among such scales, the objective and continuous evaluation of wearable devices is increasingly utilized by clinicians and patients. S...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Conclusion: Our results suggest that the detection of pαSyn, but not αSyn, especially in the muscularis propria of GI tracts, could be a sensitive prodromal biomarker for PD. PMID: 33029342 [PubMed]
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Conditions:   Parkinson Disease;   Cognition Disorder;   Motor Disorders Intervention:   Other: Cognitive training Sponsors:   Federal University of Paraíba;   Universidade Federal do Rio Grande do Norte Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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