Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation

This study demonstrates that biased agonists of CXCR3 produce distinct physiological effects, suggesting discrete roles for different endogenous CXCR3 ligands and providing evidence that biased signaling can affect the clinical utility of drugs targeting CXCR3 and other chemokine receptors.

Source: Signal Transduction Knowledge Environment - November 6, 2018 Category: Science Authors: Smith, J. S., Nicholson, L. T., Suwanpradid, J., Glenn, R. A., Knape, N. M., Alagesan, P., Gundry, J. N., Wehrman, T. S., Atwater, A. R., Gunn, M. D., MacLeod, A. S., Rajagopal, S. Tags: STKE Research Articles Source Type: news