Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet

Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Marina Barcelos de Miranda, Mariana Ferreira Lanna, Ana Luiza Barros Nascimento, Carmen Aparecida de Paula, Marcelo Eustáquio de Souza, Mariane Felipetto, Lucíola da Silva Barcelos, Sandra Aparecida Lima de MouraAbstractThe occurrence of inflammation and protein malnutrition is an aggravating risk factor for morbidity and mortality in the clinical setting. The green propolis, a natural product made by Apis mellifera bees from Baccharis dracunculifolia resin, has therapeutic potential to modulate chronic inflammation. However, its effect on inflammation in an impaired nutritional status is not known. The aim of this study was to characterize the effects of the administration of the hydroalcoholic extract of the green propolis in the chronic inflammatory process of mice submitted to a low-protein diet. For this, we used the subcutaneous implantation of sponge disks as an inflammatory model and the animals were distributed in the following groups: standard protein diet (12% protein content), control treatment; standard protein diet, propolis treatment; low-protein diet (3% protein content), control treatment; low-protein diet, propolis treatment. Propolis was given daily at a dose of 500 mg/kg (p.o.) during a period of 7 or 15 days. Our main findings show that animals fed with standard protein diet and treated with propolis had low levels of red blood cells, hemoglobin, and hematocrit, ...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research