Involvement of AMPK activation in the inhibition of hepatic gluconeogenesis by Ficus carica leaf extract in diabetic mice and HepG2 cells

In conclusion, FCL extract inhibits hepatic gluconeogenesis via activation of AMPK and down-regulation of gluconeogenic enzymes.Graphical abstractAMP-activated protein kinase (AMPK) plays pivotal roles in insulin sensitivity and glucose homeostasis. PEPCK, G6pase, PGC-1α, FOXO1, HNF4α are the key enzymes and transcription factors in gluconeogenesis. PGC-1α, FOXO1, HNF4α can regulate G6Pase and PEPCK enzymes gene expression.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research