Histamine H4 and H1 receptors contribute to postinflammatory visceral hypersensitivity

Conclusions
H4R and H1R antagonists dose-dependently reduce and even normalise postinflammatory visceral hypersensitivity via different underlying mechanisms but with a synergistic effect. Both receptor subtypes represent promising targets for the treatment of postinflammatory visceral hypersensitivity.

Source: Gut - October 31, 2014 Category: Gastroenterology Authors: Deiteren, A., De Man, J. G., Ruyssers, N. E., Moreels, T. G., Pelckmans, P. A., De Winter, B. Y. Tags: Endoscopy, Gastrointestinal hormones, Colon cancer Neurogastroenterology Source Type: research