Do Birthweight and Weight Gain During Infancy and Early Childhood Explain Variation in Mammographic Density in Women in Midlife? Results From Cohort and Sibling Analyses.

Do Birthweight and Weight Gain During Infancy and Early Childhood Explain Variation in Mammographic Density in Women in Midlife? Results From Cohort and Sibling Analyses. Am J Epidemiol. 2018 Nov 01;: Authors: Terry MB, Cohn BA, Goldberg M, Flom JD, Wei Y, Houghton LC, Tehranifar P, McDonald JA, Protacio A, Cirillo P, Michels KB Abstract High birthweight is associated with increased breast cancer risk, and less consistently with higher mammographic density (MD). In contrast, adolescent body size has been consistently, inversely associated with both MD and breast cancer risk. It is unclear when the direction of these associations change and whether weight gain in infancy is associated with MD. We evaluated the associations of birthweight and postnatal weight (measured at 4 months, 1 year and 4 years) by absolute and velocity measures (relative within-cohort percentile changes) with adult MD, assessed using Cumulus, using linear regression models with GEE to account for correlation between siblings in the Early Determinants of Mammographic Density (EDMD) study (1959-2008, n = 700 women and 116 sibling sets, mean age = 44.1 years). Birthweight was positively associated with dense area (β = 3.36 per 1 kg increase, 95% confidence interval (CI): 0.06, 6.66). Weight gain from 0 to 4 months and 1 to 4 years were inversely associated with dense area(β for 10 unit increase in weight percentile = -0.65, 95% CI: -1.23, -0.07, and β ...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research