Low levels of alpha-synuclein in peripheral tissues are related to clinical relapse in relapsing-remitting multiple sclerosis: A pilot cross-sectional study
The protein alpha-synuclein ( α-Syn) has been linked to neuroinflammatory conditions. We investigated whether the presence of α-Syn in peripheral tissues is a surrogate of brain inflammatory status in a small group of relapsing-remitting multiple sclerosis (RRMS) patients in a pilot cross-sectional study. Skin biopsies and per ipheral blood were sampled from 34 healthy controls and 23 MS patients for measurement of α-Syn levels. Within the RRMS group 15 patients were in remission, and 8 patients were in the relapsing phase.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Manuel Mej ía, Ildefonso Rodríguez-Leyva, Fernando Cortés-Enríquez, Erika Chi-Ahumada, Diana Patricia Portales Pérez, Miguel Angel Macías-Islas, María E. Jiménez-Capdeville Source Type: research