The relationship between muscle mass and function in cancer cachexia: smoke and mirrors?

We report similar confirmatory findings in other studies, and describe potential reasons for these observations. Summary The relationship between muscle mass and muscle function is complex and unlikely to be linear. Furthermore, the relationship is influenced by the techniques used to assess nutritional endpoints [e.g. computed tomography (CT)]; the nature of the chosen physical function outcome measures; and the sex and severity of the recruited cachectic patients. Such factors need to be considered when designing intervention trials for cancer cachexia with functional endpoints.
Source: Current Opinion in Supportive and Palliative Care - Category: Palliative Care Tags: CACHEXIA, NUTRITION AND HYDRATION: Edited by Aminah Jatoi and Barry J.A. Laird Source Type: research

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Conclusion: The incidence of bleomycin induced pulmonary toxicity and mortality was significantly higher in our study compared to that of other Western studies. This could be probably due to the increased susceptibility of the Indian patients to bleomycin induced lung damage. In a highly curable cancer such as HL, it is unacceptable to have such a high life-threating toxicity. Hence, an alternative chemotherapy regimen without bleomycin is to be explored which would prevent toxicity and hence the compromise on survival.
Source: Indian Journal of Palliative Care - Category: Palliative Care Authors: Source Type: research
ConclusionsMTV, a volumetric parameter of FDG PET/CT, is an important independent prognostic factor for PFS to the first line palliative treatment, irrespective of tumor subtype, in patients with MBC.Legal entity responsible for the studyThe authors.FundingHas not received any funding.DisclosureY.H. Park: Advisory / Consultancy, Research grant / Funding (self): AstraZeneca; Advisory / Consultancy, Research grant / Funding (self): Pfizer; Advisory / Consultancy, Research grant / Funding (self): Eisai; Advisory / Consultancy, Research grant / Funding (self): Novartis; Research grant / Funding (self): Roche. All other authors...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
llian Breast cancer represents a leading cause of death worldwide. Despite the advances in systemic therapies, the prognosis for patients with breast cancer liver metastasis (BCLM) remains poor. Especially in case of failure or cessation of systemic treatments, surgical resection for BCLMs has been considered as the treatment standard despite a lack of robust evidence of benefit. However, due to the extent and location of disease and physical condition, the number of patients with BCLM who are eligible for surgery is limited. Palliative locoregional treatments of liver metastases (LM) include transarterial embolization...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
This study assessed the risk factors of fistula based on clinical information on patients with chemoradiotherapy for T4-EC.MethodsWe retrospectively reviewed the clinical data of 59 T4-EC patients who had squamous cell carcinoma without any fistula before receiving definitive or palliative chemoradiotherapy.ResultsA fistula was observed in 18 patients (31%) throughout their clinical course. The overall survival in the fistula group was significantly shorter than that in the non-fistula group (259 vs. 346  days;p = 0.0341). The axial tumor size on computed tomography (CT) was confirmed as an independent r...
Source: Esophagus - Category: Gastroenterology Source Type: research
Here, we report a case of pyothorax ‐associated angiosarcoma. Our patient had computed tomography (CT) scans of the chest annually to monitor chronic empyema, and to screen for cancers. Our patient was diagnosed with angiosarcoma within a month period after complaining of chest pain. This is the very first report on angiosarcoma who se aggressive growth could be observed on CT imaging. An 82 ‐year‐old man with chronic tuberculous empyema visited our hospital for an annual computed tomography (CT) scan. No differences were noted between the CT scan at presentation and a scan performed a year previously in August 2017....
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Conclusion: CT-guided 125 I seed implantation represents an effective and safe palliative care for patients with MESCC, which can effectively relieve pain and spinal cord compression and improve nerve function and quality of life.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Conclusions11C-choline PET/CT and the correspondent local treatments may play an important role in the treatment sequence of CRPC in selected patients.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
In conclusion, patients with tumor spread to the anterolateral/lateral portion of vertebrae bodies based on CT scan diagnosis experienced severe cancer pain. These patients needed strong opioids or palliative spinal irradiation for pain relief. PMID: 31214273 [PubMed - in process]
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
Publication date: Available online 18 June 2019Source: Respiratory Medicine Case ReportsAuthor(s): Daisuke Shibahara, Makoto Furugen, Shiho Kasashima, Kozue Kaneku, Tomoko Yamashiro, Wakako Arakaki, Takuro Ariga, Eriko Atsumi, Hajime Aoyama, Hirofumi Matsumoto, Hiroki Maehara, Jiro FujitaAbstractA 70-year-old Japanese man with stage IV EGFR-mutated lung adenocarcinoma complained of right mild back pain. The patient had been heavily treated with several cytotoxic or molecular targeted agents for 10 years and received a palliative radiation therapy of 2nd sacral vertebra 5 years ago. Computed tomography showed the abnormal l...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
This study has terrific significance and could be extremely important,” Harbut, clinical professor of internal medicine at Wayne State University and Michigan State University, told The Mesothelioma Center at Asbestos.com. “We’re going after this one with great guns.” The study is part of a new partnership between Owlstone Medical — the Breath Biopsy inventor in the United Kingdom — and the International Association of Heat and Frost Insulators and Allied Workers, a building trade union that covers the United States and Canada. Early Diagnosis Still a Rarity The first part of the study ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
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