Father sues Legacy Health for $21.5M on behalf of brain-damaged daughter
A father has filed a $21.5 million malpractice lawsuit on behalf of his daughter, alleging she suffered brain damage as a newborn because Legacy Health delayed diagnosing and treating her respiratory failure. Justin Barnett filed says in a complaint filed in Multnomah County Circuit Court that his daughter was born premarturely at Legacy Emanuel Hospital on Oct. 14, 2013. The baby’s mother tested positive for Group B Streptococcus, placing the baby at risk of infection. She was hospitalized in…
A pilot study will compare two tests with the current approach of testing only "high risk" pregnant women.
Group B streptococcus (GBS), also known as Streptococcus agalactiae (S. agalactiae), is a bacterium surrounded by a polysaccharide capsule. Based on the serological reaction against the polysaccharide capsule or as determined by a multiplex polymerase chain reaction assay, GBS strains can be divided into 10 distinct serotypes (Ia, Ib, and II to IX). Multilocus sequence typing is also used to classify GBS strains. More than 750 sequence types (STs) have been identified, and most human isolates are clustered into six major clonal complexes.
CONCLUSION: Exogenous surfactants may provide a therapeutic alternative for neonatal lung infection by suppressing pulmonary GBS proliferation and translocation into systemic circulation, alleviating inflammatory injury and regulating growth factor expression. PMID: 31086290 [PubMed - as supplied by publisher]
In this study, we show that a vaccine based on a mixture of rSIP and AbISCO-100 adjuvant reduces GBS vaginal colonization in mice and induces antibodies with opsonophagocytic activities. Moreover, the passive transfer of sera and total T-cells from mice immunized with rSIP mixed with AbISCO-100 to unvaccinated mice decreases vaginal GBS colonization in an infected mouse. This is the first report of cellular immunity associated with rSIP-based vaccine testing in a mouse model of GBS infection.
Condition: GBS Intervention: Other: GBS vaginal double swab Sponsors: Carmel Medical Center; Cepheid Not yet recruiting
Fleur Edwards, of Devon, went to sleep in August 2018, but never woke up. She had been in contact with many adults the hours before her death, caused by group B strep infection.
(Abstracted from J Matern Fetal Neonatal Med 2018;31(24):3293–3300) Maternal colonization with group B streptococcus (GBS) leading to neonatal sepsis remains a predominant cause of neonatal morbidity and mortality in the world. Many countries have adopted screening strategies, such as the antepartum GBS screening culture at 35 to 37 weeks of pregnancy (antepartum culture), to identify women who need intrapartum antibiotic prophylaxis (IAP) in order to avoid the GBS peripartum transmission to the fetus.
CONCLUSION: The use of prophylactic antibiotic treatment considerably reduced the risk of peritonitis after invasive gynecologic procedures. PMID: 31028109 [PubMed - as supplied by publisher]
Discussion 1. What are indications for an exchange transfusion? 2. What are potential risks of partial exchange or exchange transfusion? 3. What are causes of anemia in different age groups? Related Cases Disease: Polycythemia | Blood and Blood Disorders Symptom/Presentation: Abnormal Laboratory Test | Respiratory Distress Specialty: Hematology | Neonatology Age: Premature Newborn To Learn More To view pediatric review articles on this topic from the past year check PubMed. Evidence-based medicine information on this topic can be found at SearchingPediatrics.com and the Cochrane Database of Systematic Reviews. Infor...