Outcome of membranoproliferative glomerulonephritis and C3-glomerulopathy in children and adolescents

ConclusionsIC-MPGN and C3G are rare disorders in children. Most patients have signs of complement activation associated with risk polymorphisms or likely pathogenic variants in complement-regulating genes. Steroids and mycophenolate mofetil seem to be effective and for some patients, eculizumab might be a treatment option. Outcome is heterogeneous and precise differentiation between IC-MPGN and C3G is still pending.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research