UCP2 Mitigates the Loss of Human Spermatozoa Motility by Promoting mROS Elimination

Conclusion: These results suggest an UCP2 –mROS–motility regulatory system exists for maintaining spermatozoa mobility in humans. In such a system, UCP2 fulfills its function by promoting mROS elimination, and slightly over-produced mROS in turn serves as a signal to stimulates the expression of UCP2. This regulatory system represents a new potential target for the discovery of novel pharmaceuticals for the treatment of patients with low spermatozoa motility.Cell Physiol Biochem 2018;50:952 –962
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research