SIRT1: The Value of Functional Outcome, Stroke-Related Dementia, Anxiety, and Depression in Patients with Acute Ischemic Stroke

Background: The outcome of ischemic stroke depends on multiple factors and their function of each other. Studies have shown that Sirtuin1 (SIRT1) plays a chief role in the key procedure during ischemia/hypoxia by protecting against cellular stress and controlling the metabolic pathways. Aims: To explore the alterations in serum SIRT1 concentrations in acute ischemic stroke (AIS) patients and the relationship between SIRT1 and poststroke dementia, anxiety, and depression. Methods: One hundred and twenty four consecutive patients with clinically diagnosed AIS were recruited to participate in the study.

Source: Journal of Stroke and Cerebrovascular Diseases - October 23, 2018 Category: Neurology Authors: Xue Liang, Yang Liu, Shiyu Jia, Xiaomin Xu, Meixue Dong, Youdong Wei Source Type: research