MLN64 deletion suppresses RANKL-induced osteoclastic differentiation and attenuates diabetic osteoporosis in streptozotocin (STZ)-induced mice.

In conclusion, the results in our study suggested that MLN64 played a critical role in the meditation of osteoclastic differentiation, and its suppression alleviated diabetic osteoporosis in STZ-induced mice. Thus, MLN64 could be served as an essential target for developing effective therapeutic strategy to prevent diabetic osteoporosis.
PMID: 30322615 [PubMed - as supplied by publisher]

Source: Biochemical and Biophysical Research communications - October 12, 2018 Category: Biochemistry Authors: Lei C, Xueming H, Ruihang D Tags: Biochem Biophys Res Commun Source Type: research