Imaging biomarkers of epileptogenecity after traumatic brain injury - Preclinical frontiers.

Imaging biomarkers of epileptogenecity after traumatic brain injury - Preclinical frontiers.
Neurobiol Dis. 2018 Oct 12;:
Authors: Immonen R, Harris NG, Wright D, Johnston L, Manninen E, Smith G, Paydar A, Branch C, Grohn O
Abstract
Posttraumatic epilepsy (PTE) is a major neurodegenerative disease accounting for 20% of symptomatic epilepsy cases. A long latent phase offers a potential window for prophylactic treatment strategies to prevent epilepsy onset, provided that the patients at risk can be identified. Some promising imaging biomarker candidates for posttraumatic epileptogenesis have been identified, but more are required to provide the specificity and sensitivity for accurate prediction. Experimental models and preclinical longitudinal, multimodal imaging studies allow follow-up of complex cascade of events initiated by traumatic brain injury, as well as monitoring of treatment effects. Preclinical imaging data from the posttraumatic brain are rich in information, yet examination of their specific relevance to epilepsy is lacking. Accumulating evidence from ongoing preclinical studies in TBI support insight into processes involved in epileptogenesis, e.g. inflammation and changes in functional and structural brain-wide connectivity. These efforts are likely to produce both new biomarkers and treatment targets for PTE.
PMID: 30321600 [PubMed - as supplied by publisher]

Source: Neurobiology of Disease - October 12, 2018 Category: Neurology Authors: Immonen R, Harris NG, Wright D, Johnston L, Manninen E, Smith G, Paydar A, Branch C, Grohn O Tags: Neurobiol Dis Source Type: research