Correlation between neurocognitive impairment and DNA methylation of MMP-9 gene in patients with deficit schizophrenia

Deficit schizophrenia (DS) is defined as a homogeneous subtype of schizophrenia characterized by primary and persistent negative symptoms (Carpenter et al., 1988; Kirkpatrick and Galderisi, 2008). Compared to non-deficit schizophrenia (NDS), DS patients exhibited uniqueness in clinical characteristics, such as a higher rate in males, summer birth, poorer treatment responses, and long-term functional outcome. Most evidence suggested more severe neurocognitive impairments were observed in patients with DS relative to NDS (Cascella et al., 2008).
Source: Schizophrenia Research - Category: Psychiatry Authors: Tags: Letter to the Editor Source Type: research