Early adolescent Rai1 reactivation reverses transcriptional and social interaction deficits in a mouse model of Smith-Magenis syndrome [Medical Sciences]

Haploinsufficiency of Retinoic Acid Induced 1 (RAI1) causes Smith–Magenis syndrome (SMS), a syndromic autism spectrum disorder associated with craniofacial abnormalities, intellectual disability, and behavioral problems. There is currently no cure for SMS. Here, we generated a genetic mouse model to determine the reversibility of SMS-like neurobehavioral phenotypes in Rai1 heterozygous...

http://www.pnas.org/content/115/42/10744.short?rss=1

Source: Proceedings of the National Academy of Sciences - October 16, 2018 Category: Science Authors: Wei-Hsiang Huang, David C. Wang, William E. Allen, Matthew Klope, Hailan Hu, Mehrdad Shamloo, Liqun Luo Tags: Biological Sciences Source Type: research