Leptin and the intervertebral disc: a biochemical link exists between obesity, intervertebral disc degeneration and low back pain —an in vitro study in a bovine model

ConclusionsLeptin can initiate processes involved in IVD degeneration. This effect is potentiated in an environment of existing degeneration and inflammation. Hence, a biochemical mechanism may underlie the link between obesity, intervertebral disc degeneration and low back pain.Graphical abstractThese slides can be retrieved under Electronic Supplementary Material.
Source: European Spine Journal - Category: Orthopaedics Source Type: research