The yield of full BRCA1 / 2 genotyping in Israeli high-risk breast/ovarian cancer patients who do not carry the predominant mutations

ConclusionsThe overall yield of comprehensiveBRCA1/2 testing in ethnically diverse high-risk Israeli individuals is 3.3%. This is lower than expected by probability models. A slightly higher rate ofBRCA1/2 carriers was seen among ovarian cancer cases. These data should guideBRCA1/2 optimal testing strategy in Israel.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research