Lysines residing in putative small ubiquitin-like modifier (SUMO) motifs regulate fate and function of 37 KDa Laminin Receptor.

We report an inability to detect 67 LR formation, suggesting that SUMOylation does not appear to directly occur at the lysine residues proposed. However, the work revealed that these lysine mutations still appear to be important and can impact the fate and function for 37 LR, for example impairing half-life and steady state pre-mRNA levels. These results suggest that the Lys residues within putative SUMO motifs in 37 LR may indirectly coordinate with SUMO pathways. PMID: 30315854 [PubMed - as supplied by publisher]
Source: Biochimie - Category: Biochemistry Authors: Tags: Biochimie Source Type: research