Viruses, Vol. 10, Pages 558: Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies
Viruses, Vol. 10, Pages 558: Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies
Viruses doi: 10.3390/v10100558
Authors:
Mariangela Garofalo
Alessandro Villa
Nicoletta Rizzi
Lukasz Kuryk
Vincenzo Mazzaferro
Paolo Ciana
Oncolytic viruses (OV) are engineered to infect, replicate in and kill cancer cells. Currently, the OV therapeutic approach is mainly restricted to neoplasia amenable to direct local administration of viral particles, while the possibility of a systemic delivery of cancer-tropic viruses would extend the OV application to the treatment of metastatic neoplasia. Herein, we applied in vivo/ex vivo imaging to demonstrate that cancer tropism is achieved when OV are encapsulated inside extracellular vesicles (EV) administered intravenously (i.v.), but not when injected intraperitoneally (i.p.). Moreover, we show that the therapeutic procedure adopted does not alter the immunomodulatory properties of the viruses.
Source: Viruses - Category: Virology Authors: Mariangela Garofalo Alessandro Villa Nicoletta Rizzi Lukasz Kuryk Vincenzo Mazzaferro Paolo Ciana Tags: Brief Report Source Type: research