False-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With Alemtuzumab: Potential Pitfalls for the Misdiagnosis of B-Cell Neoplasms.

Conclusions: Alemtuzumab can produce direct interference during flow cytometry analysis, resulting in false-positive evidence of light chain clonality. Clinicians and laboratorians should be cognizant of this risk to avoid misdiagnosis of B-cell neoplasms. PMID: 30307483 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30307483?dopt=Abstract

Source: American Journal of Clinical Pathology - October 10, 2018 Category: Pathology Authors: Chen PP, Tormey CA, Eisenbarth SC, Torres R, Richardson SS, Rinder HM, Smith BR, Siddon AJ Tags: Am J Clin Pathol Source Type: research