Pro-resolving lipid mediators: Agents of anti-ageing?

We describe the role played by specialised proresolving lipid mediators (SPMs) in the resolution of inflammation and how insufficient levels of these mediators, or compromised responsiveness may play a role in the pathogenesis of many ageing-associated pathologies, e.g. Alzheimer's Disease, atherosclerosis, obesity, diabetes and kidney disease. Detailed examination of the resolution phase of inflammation highlights the potential to harness these lipid mediators and or mimetics of their bioactions, in particular, their synthetic analogues to promote effective resolution of inflammation, without compromising the host immune system. PMID: 30293857 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30293857?dopt=Abstract

Source: Seminars in Immunology - October 4, 2018 Category: Allergy & Immunology Authors: Doyle R, Sadlier DM, Godson C Tags: Semin Immunol Source Type: research