Heat-related chronic kidney disease mortality in the young and old: differing mechanisms, potentially similar solutions? - Ó Flatharta T, Flynn A, Mulkerrin EC.

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Source: SafetyLit - Category: International Medicine & Public Health Tags: Environmental Issues, Climate, Geophysics Source Type: news

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Authors: Uehara A, Kita Y, Sumi H, Shibagaki Y Abstract Hypomagnesemia, a side effect of proton-pump inhibitors (PPIs), can be asymptomatic. The presence of hypocalcemia or hypokalemia is indicative of hypomagnesemia; however, the concomitant use of PPIs and thiazide may mask hypocalcemia. A 79-year-old woman with a history of chronic heart failure and chronic kidney disease developed symptomatic hypocalcemia and hypomagnesemia. Five weeks earlier, she had developed thiazide-induced hyponatremia, so thiazide had been discontinued. Reviewing the patient's charts revealed that three discontinued thiazide administrati...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
Anogenital skin care for elderly remains an umbrella term concerning protective and non-interventional regimens, particularly for ordinary diaper users. Diapers provide an anxiety relief for excretion, but instead raise a prevalence of genital candidiasis. Our recent investigation has demonstrated the favorable preventive effect of topical washing with miconazole nitrate-containing soap to diaper candidiasis. We extended this work to the therapeutic benefit of the antifungal soap in substantial cases with genital candidiasis, who had at least 1 additional risk factor including diarrhea, cerebrovascular diseases, dementia, ...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research
FRIDAY, April 19, 2019 -- Atrasentan is associated with a reduced risk for renal events in patients with type 2 diabetes and chronic kidney disease, according to a study published online April 14 in The Lancet to coincide with the International...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
PMID: 30994543 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
Calcimimetics are widely used in patients on dialysis to treat secondary hyperparathyroidism. Our current view is that bone effects are only indirect through parathyroid hormone suppression. However, because bone cells express the calcium-sensing receptor, direct calcium-sensing receptor –mediated effects are also possible. New experimental data demonstrate direct anabolic bone actions of calcimimetics, independent of parathyroid hormone suppression. Because these effects could be clinically useful, further studies are necessary to confirm the validity of this observation.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
Acid retention occurs early during the course of chronic kidney disease (CKD). Studies conducted in patients with CKD suggest that alkali supplementation may slow CKD progression. However, the diagnosis of acid retention is challenging when plasma bicarbonate concentration is still normal. In this issue, Goraya et  al. suggest that urinary citrate may predict acid retention in eubicarbonatemic patients with stages 1 and 2 CKD . Although interesting, this claim yet requires confirmation by further studies.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
Glomerular filtration rate (GFR) estimating equations are widely used, but their accuracy is limited by the need for race-ethnicity factors and imprecision of the estimated GFR. In this issue, Bukabau et  al. evaluated the accuracy of GFR estimating equations and race-ethnicity factors in 2 centers in sub-Saharan Africa. The authors determined that the African American factor is not applicable and that newer equations are not more accurate than the Chronic Kidney Disease Epidemiology Collaboration equations recommended by current guidelines.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
Discussions focused on the optimal means for measuring blood pressure (BP) as well as managing BP in CKD patients.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: KDIGO Executive Conclusions Source Type: research
A 67-year-old man began hemodialysis at age 44 years after undergoing a right nephrectomy. Whereas a preoperative ultrasound had revealed mild renal atrophy in the absence of cysts, the histopathologic analysis of the excised kidney was consistent with nonspecific chronic kidney disease. During the following decade, the remaining kidney became severely polycystic (Figure  1a and b), and the liver was occupied by several microcysts in the absence of hepatocellular dysfunction or cholestasis based on serum measurements.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
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