Neuromodulation for substance addiction in human subjects: A review

Publication date: December 2018Source: Neuroscience &Biobehavioral Reviews, Volume 95Author(s): Ausaf Bari, Jasmine DeCisare, Diana Babayan, Mariama Runcie, Hiro Sparks, Bayard WilsonAbstractSubstance abuse is one of the most prevalent and costly health problems in the world today. Standard medical therapy is often not curative, and relapse is common. Research over the past several decades on the neural underpinnings of addiction has implicated a network of structures within the brain shown to be altered in patients with substance abuse. The field of neuromodulation aims to utilize this knowledge to treat dysfunctional circuits by targeting and modulating specific brain circuits. While invasive neuromodulation such as DBS and VNS have proven to be effective in treating movement disorders, OCD and epilepsy, there is increasing interest and data with regards to its potential application for the treatment of severe, intractable addiction. Several neuromodulatory techniques and brain targets are currently under investigation in patients with various substance abuse disorders. This review aims to summarize the current state of evidence for neurosurgical neuromodulation as a therapy for substance abuse and addiction, and to provide additional expert opinions as to the obstacles and future directions of this endeavor.
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research

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Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Stereoelectroencephalography (SEEG) vs.Mindstrong HealthMood Monitoring via Invasive Brain Recordings or Smartphone SwipesWhich Would You Choose?That's not really a fair question. The ultimate goal of invasive recordings is one of direct intervention, by delivering targeted brain stimulation as a treatment. But first you have to establish a firm relationship between neural activity and mood. Well, um, smartphone swipes (the way you interact with your phone) aim to establish a firm relationship between your “digital phenotype” and your mood. And then refer you to an app for a precision intervention. Or to your t...
Source: The Neurocritic - Category: Neuroscience Authors: Source Type: blogs
Whatever your personal position on the subject of marijuana legalization, whether for medical or recreational use, a growing body of research reveals concerns over the potential harms caused by cannabis. The concerns are more than academic. With increasing public support (varying by demographic cohorts) for legalized marijuana, and 10 states legalizing recreational marijuana and 33 states where medical marijuana use is legal, the cannabis movement is just gaining steam. A new Pew Research Center report shows that 6 in 10 Americans (62 percent) say marijuana should be legal. Millennials support legalized marijuana more tha...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Memory and Perception Mental Health and Wellness Research Substance Abuse Cannabis Drug Use Marijuana side effects Source Type: blogs
What is Anxiety? Having anxiety is a difficult issue suffered by millions. It is much more than just butterflies in your stomach before going on stage or before an important event – it can be crippling and can cause severe impacts on one’s life, and you may need to be on anxiety medication to help with the symptoms. According to anxiety.org, there are many anxiety-related disorders, and they are divided into three main categories: Anxiety disorders Obsessive-compulsive and related disorders Trauma and stressor-related disorders Anxiety disorders are characterized by a general feature of excessive fear (i.e. e...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction Recovery Addiction to Pharmaceuticals Anxiety Drug Rehab Information Drug Treatment PTSD anxiety medication benzodiazepines Source Type: blogs
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Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness self improvement benefits of cbd cbd oil pickthebrain Source Type: blogs
NEW MEMBERS: Fall ‘17 Brief bios/plugs for new members (extracted from the Introduce Yourself Connect Community) After returning to school to become an OR surgical tech, Mary Mack’s heart health declined, and she quickly learned to become a strong advocate for herself. Feeling that no one was into her participatory style, Mary believes a radical change in medical student education is necessary to change the culture of medicine. She is passionate about helping to make that change happen. Her other interests include playing the guitar and speaking Mandarin Chinese. Jim Skinner created the Smart Patient Academy a...
Source: Society for Participatory Medicine - Category: General Medicine Authors: Tags: Newsletter Source Type: news
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Source: Central European Journal of Public Health - Category: International Medicine & Public Health Tags: Cent Eur J Public Health Source Type: research
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Source: International Journal of Mental Health and Addiction - Category: Addiction Source Type: research
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Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Bipolar Disorder Current Issue Drug Development Mental Disorders Mood Disorders Original Research Psychiatry Psychopharmacology disease burden expenditures major depressive disorder pharmaceutical innovation research and developmen Source Type: research
ConclusionsEpidemiological and case report evidence suggests that the antiā€epileptic and analgesic medication gabapentin is being misused internationally, with substance abuse populations at special risk for misuse/abuse.
Source: Addiction - Category: Addiction Authors: Tags: Review Source Type: research
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