The role of perineural invasion in penile cancer: a meta-analysis and systematic review.

The role of perineural invasion in penile cancer: a meta-analysis and systematic review.
Biosci Rep. 2018 Oct 02;:
Authors: Zhou X, Qi F, Zhou R, Wang S, Wang Y, Wang Y, Chen C, Wang Y, Yang J, Song N
Abstract
The significance of perineural invasion (PNI) present in penile cancer (PC) is controversial. In order to clarify the predictive role of PNI in the inguinal lymph node metastases (ILNM) and oncologic outcome of patients, we performed this meta-analysis and systematic review. The search of PubMed, EMBASE and Web of Science was conducted for appropriate studies, up to January 20th, 2018. The pooled odds ratio (OR) and hazard ratio (HR) with their 95% confidence interval (CI) were applied to evaluate the difference in ILNM and oncologic outcome between patients present with PNI and those who were absent. A total of 298 in 1001 patients present with PNI were identified in current meta-analysis and systematic review. Significant difference was observed in ILNM between PNI present and absent in patients with PC (OR=2.98, 95% CI=2.00-4.45). Patients present with PNI held a worse cancer specific survival (CSS) (HR=3.58, 95% CI=1.70-7.55) and a higher cancer specific mortality (CSM) (HR=2.20, 95% CI=1.06-3.82) than those cases without PNI. This meta-analysis and systematic review demonstrated the predictive role of PNI in ILNM, CSS and CSM for penile cancer patients.
PMID: 30279203 [PubMed - as supplied by publisher]

Source: Bioscience Reports - October 2, 2018 Category: Biomedical Science Authors: Zhou X, Qi F, Zhou R, Wang S, Wang Y, Wang Y, Chen C, Wang Y, Yang J, Song N Tags: Biosci Rep Source Type: research