Structural studies of calcium channel blockers used in the treatment of hypertension - 1 H and 13 C NMR characteristics of nifedipine analogues.

Structural studies of calcium channel blockers used in the treatment of hypertension - 1 H and 13 C NMR characteristics of nifedipine analogues.
Magn Reson Chem. 2018 Sep 26;:
Authors: Szeleszczuk Ł, Zielińska-Pisklak M, Pisklak DM
Abstract
The 1 H and 13 C NMR spectroscopy in solution was applied to characterize a series of active pharmaceutical ingredients (API) belonging to the class of calcium channel blockers, a group of drug substances extremely sensitive to UV radiation: nifedipine (1), nitrendipine (2), nisoldipine (3), nimodipine (4), nilvadipine (5), felodipine (6) isradipine (7) nicardipine (8) and amlodipine besylate (9). Two-dimensional NMR experiments (COSY, HSQC, HMBC) allowed the unequivocal assignments of peaks in the 1 H and 13 C spectra in solution and in some cases enabled editing of incorrect assignments appearing in the scientific literature. Various nifedipine derivatives can be easily distinguished based on their 13 C chemical shifts. 1 H and 13 C chemical shifts analysis provides fast identification of the drug substance and ensures its stability in the commercial dosage forms from different sources.
PMID: 30255952 [PubMed - as supplied by publisher]

Source: Magnetic Resonance in Chemistry : MRC - September 26, 2018 Category: Chemistry Authors: Szeleszczuk Ł, Zielińska-Pisklak M, Pisklak DM Tags: Magn Reson Chem Source Type: research