C5aR1 interacts with TLR2 in osteoblasts and stimulates the osteoclast-inducing chemokine CXCL10.

In conclusion, C5a-stimulated osteoblasts might modulate osteoclast activity and contribute to immunomodulation in inflammatory bone disorders.
PMID: 30247799 [PubMed - as supplied by publisher]

Source: J Cell Mol Med - September 24, 2018 Category: Molecular Biology Authors: Mödinger Y, Rapp A, Pazmandi J, Vikman A, Holzmann K, Haffner-Luntzer M, Huber-Lang M, Ignatius A Tags: J Cell Mol Med Source Type: research