Synaptic plexi of U-fibre layer beneath focal cortical dysplasias: Role in epileptic networks.

CONCLUSION: U-fibre synaptic plexi contribute to excitatory circuitry in the cortex and thus to epileptic networks. Deep white matter neurones form local, less integrated plexi except transmantle dysplasias continuous with cortex. U-fibres may be a barrier to axonal penetration from deep heterotopia. Hypermetabolic neurones suggest repetitive ictogenic depolarizations. Gyral resections should include the U-fibre layer. Neuropathology reports should describe subcortical plexi. Synaptophysin immunoreactivity is a valuable supplement for this purpose. . PMID: 30232955 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30232955?dopt=Abstract

Source: Clinical Neuropathology - September 20, 2018 Category: Pathology Authors: Sarnat HB, Hader W, Flores-Sarnat L, Bello-Espinosa L Tags: Clin Neuropathol Source Type: research