Cellular signaling pathways regulating β-cell proliferation as a promising therapeutic target in the treatment of diabetes.

Cellular signaling pathways regulating β-cell proliferation as a promising therapeutic target in the treatment of diabetes. Exp Ther Med. 2018 Oct;16(4):3275-3285 Authors: Jiang WJ, Peng YC, Yang KM Abstract It is established that a decrease in β-cell number and deficiency in the function of existing β-cells contribute to type 1 and type 2 diabetes mellitus. Therefore, a major focus of current research is to identify novel methods of improving the number and function of β-cells, so as to prevent and/or postpone the development of diabetes mellitus and potentially reverse diabetes mellitus. Based on prior knowledge of the above-mentioned causes, promising therapeutic approaches may include direct transplantation of islets, implantation and subsequent induced differentiation of progenitors/stem cells to β-cells, replication of pre-existing β-cells, or activation of endogenous β-cell progenitors. More recently, with regards to cell replacement and regenerative treatment for diabetes patients, the identification of cellular signaling pathways with related genes or corresponding proteins involved in diabetes has become a topic of interest. However, the majority of pathways and molecules associated with β-cells remain unresolved, and the specialized functions of known pathways remain unclear, particularly in humans. The current article has evaluated the progress of research on pivotal cellular signaling pathways involved ...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research

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ConclusionsIn the management of DM, bringing in positive behavioral change by motivating the patient to improve treatment adherence helps overcome insulin distress and achieve treatment goals.
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
Purpose: To separately evaluate the three retinal capillary plexuses and the choriocapillaris in patients with diabetes mellitus (DM) Type 1 and Type 2, without clinical signs of diabetic retinopathy. Methods: The study was prospective and cross-sectional. Only patients with age ≤55 years were included. We used a swept-source optical coherence tomography angiography device (Triton; Topcon, Tokyo, Japan) to obtain both quantitative and qualitative analysis of the retinal capillary plexuses (superficial capillary plexus; middle capillary plexus; and deep capillary plexus) and the choriocapillaris. Results: We incl...
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
ConclusionDisease cost analyses in hospitals are required in order to prioritize healthcare services, use resources efficiently and decrease the financial burden of diseases on the society.
Source: Health Policy and Technology - Category: Health Management Source Type: research
In conclusion, all patients with DM should be undergo recommended age- and sex appropriate cancer screenings to promote primary prevention and early detection. Furthermore, cancer should be screened in routine diabetes assessment. PMID: 31902143 [PubMed - in process]
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
Although the improved control of hyperglycaemia and other cardiovascular risk factors was associated with a parallel decline of atherosclerotic cardiovascular disease (ASCVD) and death in both type 1 (T1) and type 2 (T2) diabetes mellitus (DM), the burden of death and hospitalization for ASCVD remains significantly higher by about 2-fold versus the matched non-DM population. Life style interventions, such as physical activity and healthy diet, and drugs, such as statins and low-dose aspirin, may have beneficial effects by targeting one or multiple pathways responsible for accelerated atherosclerosis and its thrombotic complications.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
The year 2021 will mark 100 years since the discovery of insulin. The discovery of insulin and the start of insulin therapy represent a marvelous multidisciplinary team effort that profoundly transformed the lives of people with diabetes mellitus (DM). Insulin treatment substantially extended the very short life span and health span of patients with type 1 diabetes (T1D). It was further shown that insulin action is lower (insulin resistance [IR]) in obesity and that IR in combination with insufficient insulin secretion is the underpinning of type 2 diabetes (T2D) stimulated momentous research on ways to enhance insulin action.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Commentary Source Type: research
With the increasing rates of childhood obesity, many women of child-bearing age are receiving a diagnosis of type 2 diabetes mellitus (T2DM) at a younger age. Our aim was to analyze a contemporary cohort of women with diabetes mellitus by type of disease for characteristics and perinatal outcomes.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Poster Session III Source Type: research
To evaluate fetal anomalies in women with type 1 and type 2 diabetes mellitus (DM).
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Poster Session IV Source Type: research
Publication date: Available online 30 December 2019Source: Microvascular ResearchAuthor(s): Patricia P. Wadowski, Alexandra Kautzky-Willer, Thomas Gremmel, Renate Koppensteiner, Peter Wolf, Sebastian Ertl, Constantin Weikert, Christian Schörgenhofer, Bernd JilmaAbstractDiabetes is associated with micro- and macrovascular complications. The aim of the study was to investigate microvascular parameters (glycocalyx dimensions, perfused and total capillary density) in vivo in patients with type 1 and type 2 diabetes mellitus.In vivo sublingual videomicroscopy using sidestream darkfield - derived imaging was performed in 36...
Source: Microvascular Research - Category: Biochemistry Source Type: research
CONCLUSION: Currently, advances in the genetics field allowed the recognition of new DM subtypes, which until now, were considered slight variations of the typical forms. Thus, it is imperative to act in the close interaction between genetics and clinical manifestations, to facilitate diagnosis and individualize treatment. PMID: 31886753 [PubMed - as supplied by publisher]
Source: Current Diabetes Reviews - Category: Endocrinology Authors: Tags: Curr Diabetes Rev Source Type: research
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